>The HBP (hexosamine biosynthetic pathway) is one of the many biochemistry pathways being studied relating to increases in body fat levels and the incidences of diabetes.Glucosamine-6-phosphate is the first step of the HBP pathway and the end product is uridine diphosphate N-acetylglucosamine which is a nucleotide sugar and a coenzyme in metabolism. The concern has been that the extra glucosamine could contribute to diabetes by interfering with the normal regulation of the hexosamine biosynthesis pathway which basically means that the extra glucosamine may interfere or compensate by decreasing the body’s ability to utilize sugars and insulin properly. It is hypothesized to mediate hyperglycaemia-induced impaired glucose transport (The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia, and ‹Baker Medical Research Institute,Prahran 3181, Victoria, Australia).Prolonged hyperglycemia (hyper=high, glyc=sugar, emia=blood) increases complications in those with diabetes and does nothing for your aesthetics either. Glucose and glucosamine cause insulin resistance over several hours by increasing metabolite flux through the hexosamine biosynthesis pathway (HBP). As most know nowadays, insulin resistance is bad news. While glucosamine may only have such a detrimental effect on those who already have blood sugar problems, it is still an interesting thing to consider if you are a physique athlete or someone just looking to drop those last few pounds who supplements with glucosamine and have hit an unbreakable plateau or have noticed some of the symptoms of insulin resistance:increase in blood pressure, brain fogginess, depression, fatigue, weight gain (especially in abdominal area), higher blood concentration of triglycerides, and intestinal bloating, you may want to nix the glucosamine. While I am sure that glucosamine supplementation will only have this negative effect on a few out there, it is still an interesting thing to consider.